Affymetrix® Cancer Community
Affymetrix is dedicated to providing innovative genomic analysis tools and educational resources for the cancer research community. Learn from peers how our unique solutions are applied in cancer research today from discovery to clinical research and validation.
- View presentations from leading cancer researchers
- Learn more about Affymetrix solutions for cancer research
- Browse the list of useful documents on cancer research
European translational cancer research seminar series:
Unlock the full potential inside your FFPE samples
Affymetrix hosted a series of translational cancer research seminars at some of the most prestigious academic cancer centers in Europe. The seminars focused on the challenges associated with successfully obtaining genomic profiles from formalin-fixed paraffin embedded (FFPE) tissue – an important but challenging sample source for clinical cancer researchers. View the presentations to understand how Affymetrix solutions are used for FFPE tissue analyses and:
- Enabled leading oncologists to uncover genome-wide copy number aberrations in rare pediatric cancers (Joshua Schiffman, MD, University of Utah, USA)
- Helped identify novel prognostic biomarkers in solid and hematologic malignancies by SNP based copy number analysis (Eugène Verwiel, Radboud University Nijmegen Medical Center, Netherlands)
- Used gene expression arrays to classify different diffuse large B-cell lymphoma subtypes with FFPE samples (Kim Linton, PhD, University of Manchester, UK)
- Discovered a complex gene expression signature de novo from FFPE samples to differentiate between different cancer types (John Hall, PhD, Paterson Institute for Cancer Research, UK)
- Advanced the discovery of novel biomarkers using cancer-specific gene expression microarray-based tests (Austin Tanney, PhD, Almac Diagnostics Ltd, UK)
- Led to the acceleration of target validation using a unique in situ RNA assay that allows the visualization of a single mRNA copy in single cells (Paul Turner, PhD, Affymetrix UK Ltd)
- Enabled the development of intuitive data analysis solutions for DNA copy number aberration detection (Zhiwei Che, PhD, BioDiscovery Inc, USA)
"For Research Use Only. Not for use in diagnostic procedures."
Keynote speakers and presentations
DNA copy number analysis
Identifying genomic biomarkers for translation in pediatric cancer using OncoScan™ FFPE Express
Assistant Professor of Pediatric Hematology and Oncology, University of Utah, USA
Gene expression and miRNA analysis
Expression profiling of archival FFPE samples
Research Associate, Paterson Institute of Cancer Research, Manchester, UK
Microarray-based biomarker discovery: a new trick for old tissues?
Senior Lecturer, School of Cancer and Enabling Sciences, University of Manchester, UK
View abstract sheet from Translational cancer research seminar series
"For Research Use Only. Not for use in diagnostic procedures."
Learn more about our cancer research solutions
Affymetrix offers a comprehensive suite of cancer research solutions for studying an extensive range of genomic parameters at wide levels of complexity from the whole-genome to the single gene. Our various tools can also be applied at each stage of a basic or translational workflow from discovery to functional characterization or test development.
Genomic biomarker discovery solutions: whole-genome analysis tools
DNA copy number analysis:
- Optimized solution for solid tumor DNA copy number aberration, LOH, and allelic ratio detection in FFPE samples: OncoScan™ FFPE Express 2.0 Services*
- Solid and blood tumor DNA copy number aberration and allelic ratio detection: CytoScan® HD Array*
Gene expression profiling:
- Optimized biomarker discovery from cancer FFPE samples: Almac Xcel™ Array
- Discovery of transcript isoforms and lncRNA in FFPE samples: GeneChip® Gene 2.0 ST Arrays
- Optimized reagent kits for expression profiling from 10+ year-old FFPE samples: SensationPlus™ FFPE Reagent Kits
- Gene regulation profiling: GeneChip® miRNA 3.0 Array*
Technical and clinical validation solutions: tools for the analysis of 100's to single genes
- Multiplex, straight-from-sample gene expression assays: QuantiGene® Plex 2.0 Assay*
- RNA in situ hybridization assays for visualization of single-molecule RNA in single cells: QuantiGene® ViewRNA Assays*
- Gene regulation profiling: QuantiGene® miRNA 2.0 Assay*
- Flexible, fast mode qRT-PCR reagents: VeriQuest® Real-time PCR Master Mixes*
Cytokine profiling solutions:
- Multiplex quantitative immuno-cytokine assays: Procarta® Cytokine and Chemokine Assays*
Diagnostic test development solutions:
- Molecular diagnostic test development tools for complex diseases: Gene profiling arrays* for expression analysis, IVD-cleared reagents and IVD-cleared instrumentation solutions
*"For Research Use Only. Not for use in diagnostic procedures."
Publications
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Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma
Sausen, M.; Leary, R. J.; Jones, S.; Wu, J.; Reynolds, C. P.; Liu, X. Y.; Blackford, A.; Parmigiani, G.; Diaz, L. A.; Papadopoulos, N.; Vogelstein, B.; Kinzler, K. W.; Velculescu, V. E.; Hogarty, M. D. Nature Genetics 45(1), NPG, 2013 PubMed -
CellLineNavigator: a workbench for cancer cell line analysis
Krupp, M.; Itzel, T.; Maass, T.; Hildebrandt, A.; Galle, P. R.; Teufel, A. Nucleic Acids Research 41(D1), D942-8, 2013 PubMed -
Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization
Tommasi, S.; Zheng, A.; Weninger, A.; Bates, S. E.; Li, X. A.; Wu, X. W.; Hollstein, M.; Besaratinia, A. Nucleic Acids Research 41(1), 182-95, 2013 PubMed -
Targeting the Phosphoinositide 3-Kinase p110-alpha Isoform Impairs Cell Proliferation, Survival, and Tumor Growth in Small Cell Lung Cancer
Wojtalla, A.; Fischer, B.; Kotelevets, N.; Mauri, F. A.; Sobek, J.; Rehrauer, H.; Wotzkow, C.; Tschan, M. P.; Seckl, M. J.; Zangemeister-Wittke, U.; Arcaro, A. Clinical Cancer Research 19(1), 96-105, 2013 PubMed -
Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence
Angelini, P. D.; Fluck, M. F. Z.; Pedersen, K.; Parra-Palau, J. L.; Guiu, M.; Morales, C. B.; Vicario, R.; Luque-Garca, A.; Navalpotro, N. P.; Giralt, J.; Canals, F.; Gomis, R. R.; Tabernero, J.; Baselga, J.; Villanueva, J.; Arribas, J. Cancer Research 73(1), 450-8, 2013 PubMed
Scientist Spotlights
- Joshua Schiffman's research on copy number changes in pediatric cancers MIP technology reveals important copy number changes in pediatric cancer
- Austin Tanney's work with FFPE tissue Discovering and developing clinically applicable expression biomarkers using archived FFPE tissue samples
Brochures
- OncoScan™ FFPE Express brochure Unlock the full potential inside your FFPE samples
- QuantiGene® ViewRNA Assays brochure RNA in situ hybridization assays for visualization of single-molecule RNA in single cells.
- FFPE Applications Solutions brochure A Platform of comprehensive genomics solutions for analyzing FFPE archival tissues from whole-genome to single molecules
- Solutions for Personalized Medicine brochure From bedside to bench and back again
Application Notes
- QuantiGene® Assays for cancer and disease research application note Multi- and single-plex gene expression quantitation and in situ hybridization assays in cancer research.
Product Spotlight
- Affymetrix® Gene Profiling Array and Reagents product spotlight The only cGMP-manufactured gene expression clinical microarray toolkit for rapid and cost-effective diagnostic test development
"For Research Use Only. Not for use in diagnostic procedures."
Scientific Communities
COMING SOON
Archived Webinars +
Clinical Validation of Cancer Biomarker Signatures using Array Technology Webinar
Cancer Genomics Webinar
Circulating Tumor Cells Webinar
Warning! The earliest signals for cancer - miRNA regulation
The Hunt for Missing Heritability
Latest Events
13th International Conference on Malignant Lymphoma (13 ICML)
6/19/2013 - 6/22/2013
9th European Cytogenetics Conference
6/29/2013 - 7/02/2013
5th WIN symposium
7/10/2013 - 7/12/2013
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Genomic Applications
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